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MTHFR 677 CC Variant Linear Regression Results for Duration of Illness On linear regression analysis for DOI, the MTHFR 677 CC variant ( n 60, prevalence 48.5%, maximum DOI 44 years, mean DOI 7.18 years) yielded a predictive model containing molecular biomarkers that were characteristic of a low methylation state (NA, DA, AD/MHMA, DA × 5-HIAA)