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Activated Nrf2 binds to antioxidant response elements (AREs) and translates to the nucleus, ultimately initiating the expression of downstream target genes, such as heme oxygenase-1 (HO-1), NAD(P)H:quinone oxidoreductase 1 (NQO1), and glutamate–cysteine ligase catalytic (GCLC) subunit
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