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The attenuated were progressive cerebral edema, which may the net capillary filtration increase, and intracerebral and subarachnoid hemorrhage, which may additionally compromise the brain tissue [60]

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The evidence suggests that an interaction between high folate and low vitamin B-12 does in fact exist, that the biochemical response to this interaction is paradoxical, and that it represents a novel (acquired) vitamin B-12 deficiency state with a specific etiology